Introduction
Lacticaseibacillus paracasei (formerly Lactobacillus paracasei) is one of the species isolated from both artisanal fermented beverage's starters. Although it is not the predominant species in kefir or water kefir, it may contribute to their health-promoting properties. It belongs to the genus Lacticaseibacillus (formerly Lactobacillus casei group (LCG)), which is composed of the closely related species L. casei, L. paracasei and L. rhamnosus, among others and contains several strains with a long history of apparently safe use in food and agricultural applications that have been studied for their health-promoting properties.
As described above, many studies of EPS from L. paracasei strains are described in the literature. However, when it comes to strains isolated from kefir and water kefir, only a few reports have been published. These include the EPS-producing L. paracasei strain isolated from Tibetan kefir that ejects a protective effect against Salmonella pullorum infection in chicks when administered in combination with L. plantarum Zhang-LL. Nevertheless, it is not possible to attribute this health benefit exclusively to the strain or its EPS.
As was demonstrated by the literature reviewed, Lacticaseibacillus paracasei (formerly Lactobacillus paracasei) is one of the species isolated from artisanal fermented beverages, such as kefir (fermented milk drink) and water kefir (fermented non-dairy beverage), that is gaining attention to the scientific community as novel strains for application in the food industry. When a new isolate is obtained, the first challenge is the selection of an adequate method for identification to avoid mislabeling in products, scientific reports and the publication of DNA sequences. A special focus must be to unequivocally identify L. paracasei strains and differentiate from other species of the Lacticaseibacillus genus.
- Depending on the experimental setting, L. paracasei had different effects on cytokines.
- It both elevated and suppressed pro-inflammatory cytokines TNF-α, decreased or increased IL-1β, and inhibited or elevated IFN-γ.
- L. paracasei mostly induced IL-12 [in some studies decreased: , and increased the proportion of NK cells, while reducing the Th-2 response.
- L. paracasei mostly increased IL-10 [a study where IL-10 is decreased].
- L. paracasei decreased TGF-β1, and increased TGF-β2.
- L. paracasei increased IL-8 , decreased IL-2, IL-4, IL-5, and IL-13. and both decreased and increased IL-6.
- L. paracasei increased IgA, and decreased IgG4 and IgE.
- L. paracasei stimulated iNOS and NO.
- L. paracasei increased RANTES, IP-10 and ANGPTL4.
- L. paracasei lowered PPAR-γ.
- It decreased MIP-1α, CCL-20, PTGS2, COX-2, PGE2, TLR-4, NOX-4, MCP-1, PPAR-δ, CCAAT/ C/EBPβ, C/EBPα and HR-LPL.
- L. paracasei increased CD4+ T cell and B cell proliferation and upregulated the CD4+CD25+Foxp3+Treg cell responses.
- It reduced neutrophil infiltration and attenuated eosinophil influx in the lungs.
- L. paracasei increased the expression of almost all TLR signaling genes.
Dosage
There is no exact proper dosage of probiotics for everyone, however, most targeted probiotic supplements will deliver strains at 1 to 30 billion CFU per serving.
Most targeted probiotic supplements will deliver strains at 1 to 10 billion CFU per serving.
For products featuring multiple strains, the total CFU can obviously also vary but are typically 20 billion CFU and up.
Thus pls follow physician's guidance and instruction enclosed.
Storage
Keep at 5-15 DC and dry out of sunlight, keep away from children.
More;
| LIST OF STRAINS |
| Probiotics |
Strain Number |
Type(CFU/g) |
|
| Lactiplantibacillus plantarum |
Lp3a |
5-500B |
|
| Lacticaseibacillus rhamnosus |
LR05 |
5-400B |
|
| Lacticaseibacillus casei |
LC11 |
5-400B |
|
| Lacticaseibacillus paracasei |
LPC45 |
5-400B |
|
| Lactobacillus fermentum |
LF021 |
5-300B |
|
| Lactobacillus salivarius |
LS01 |
5-100B |
|
| Lactobacillus reuteri |
LR06 |
5-200B |
|
| Lactobacillus acidophi/us |
LA16 |
5-200B |
|
| Lactobacillus helveticus |
LH030/LZ-R-5 |
5-200B |
|
| Lactobacillus crispatus |
LCP051 |
5-100B |
|
| Lactobacillus gasseri |
LG021/LG019 |
5-200B |
|
| Lactobacillus johnsonii |
LJ10 |
5-100B |
|
| Lactobacillus delbrueckii subsp. bulgaricus |
LB45 |
5-20B |
|
| Bifidobacterium animalis subsp. lactis |
Bla019 |
5-400B |
|
| Bifidobacterium animalis subsp. animalis |
BA023 |
5-500B |
|
| Bifidobacterium breve |
BB033 |
5-200B |
|
| Bifidobacterium longum subsp. longum |
BL5b |
5-100B |
|
| Bidobacterium longum subsp. infantis |
BI08 |
5-50B |
|
| Bifidobacterium bifidum |
BMC31 |
5-200B |
|
| Bifidobacterium adolesentis |
BAA021 |
5-100B |
|
| Streptococcus salivarius subsp. thermophilus |
ST076 |
5-300B |
|
| Pediococcus pentosaceus |
PP016 |
5-300B |
|
| Pediococcus acidolactici |
PAL31 |
5-400B |
|
| Leuconostoc mesenteroides subsp. mesenteroides |
LCM020 |
5-200B |
|
| Weizmannia coagulans |
BC01 |
5-100B |
|
| Akkermansia muciniphila |
AMP018 |
5-200B |
|
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