Natural Degreasing and Reduce Blood Lipid Bacteria (GKM3)

• Customization: Available
• CAS No.: N
• Formula: N
• Model NO.: LP-KFY04
• Resource: Natural
• Smell: Addible
• Appearance: Dry Powder
• Cfu Density: 200b/G
• Transport Package: Plastic
• Specification: TBC
• Trademark: N
• Origin: China
• HS Code: 21069090
• Production Capacity: 5, 000kg/M

Product Description

Introduction
It has been an issue that population-suffered cognitive impairment has become bigger following the growth of the amount of older individuals in the last decade. According to the report from the World Health Organization (WHO), the number of people with cognitive decline, which was more than 46.8 million in 2015, will reach over 74.7 million in 2030, which is almost increased by half within fifteen years. Aging, recognized as a strong correlation with cognitive impairment, is generally thought to be associated with oxidative stress, which is involved in the accumulation of free radicals and promoted many physiological dysfunctions especially in the brain, an oxygen-sensitive organ, leading to degenerative symptoms such as memory loss and decline of learning ability.
L. plantarum GKM3 was isolated from Chinese mustard (Brassica juncea) and preserved at the Bioresource Collection and Research Center, Taiwan (BCRC), with the collection number 910787. First, GKM3 was cultured with a MRS (BD Co., Franklin Lakes, NJ, USA) broth at 37 °C for 18 h in the test tube. With 0.01% inoculation, the GKM3 seed culture was scaled up in 50 L fermenter under a pH 6.0 control at 37 °C for 18 h with a designed medium (5% glucose, 2% yeast extract, 0.05% MgSO₄, 0.1% K₂HPO₄, and 0.1% Tween 80). Then, the fermented bacteria were harvested by centrifugation at 3800 rpm for 10 min, washed with phosphate saline buffer twice, and the pellet was mixed with 10% milk for lyophilization. The dosages of L. plantarum GKM3 freeze-dried powder in this study were adjusted to 5.1 × 10⁹ cfu/kg B.W./day as the high dose and 1.0 × 10⁹ cfu/kg B.W./day as the low dose for the mouse model by gavage.

The β-amyloid participation in SAMP8 mice brains (40X) after 14 weeks of probiotic GKM3 consumption. (A): control male; (B): GKM3 low-dose male; (C): GKM3 high-dose male; (D): control female; (E): GKM3 low-dose female; (F): GKM3 high-dose female; and (G): the percentage of the amyloid-β participation area. The arrows point to the participation of amyloid-β. Values are presented as mean ± S.E.M. (n = 5). * p < 0.05 was regarded as a significant difference (one-way ANOVA).
Body weight changes of mice in different groups. * p < 0.05 compared with ovariectomized (OVX) mice.

Dosage
Pls follow physician's guidance or instructions enclosed.
Storage
Keep 5-15 DC and dry out of sunlight.

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