Paradigm for Next-Generation Beneficial Microorganisms Akk

• Customization: Available
• CAS No.: N
• Formula: N
• Model NO.: AMP018
• Packaging Material: Plastic
• Storage Method: Normal
• Shelf Life: >12 Months
• Nutrient Composition: Protein
• Resource: Natural
• The content of active substances: 31%~60%
• Appearance: Dry Powder
• Smell: Addible
• Density: From 5b-100b/G
• Transport Package: Bagged
• Specification: TBC
• Trademark: N
• Origin: China
• HS Code: 21069090
• Production Capacity: 500kg/M

Product Description

Introduction

As a mucin utilizing specialist¹, Akkermansia muciniphila has been highly considered as one of the next-generation probiotics (NGPs) and is regarded to play an important role in the maintenance of the intestinal epithelial barrier. A typical cycle of intestinal inflammation is driven by abnormal interactions among genetic risk factors, environmental triggers (microbiota), modifiers, and the host's immune system. Akkermansia muciniphila widely exists in the GIT of multiple animals including humans, mice, cattle, guinea pigs, swine, rabbits, ostriches and chickens. In infants and healthy adults, A. muciniphila can account for 1~3% of total fecal cells, during which the excessive degradation of mucin allows pathogens to invade the sloughed intestinal mucosa. In such cases, supplement with adequate numbers of A. muciniphila, or heat-killed A. muciniphila may safely improve the intestinal barrier in obese humans and mice fed high-fat diets. However, an excessive enrichment of A. muciniphila in mice with a specific intestinal environment may lead to the aggravation of intestinal inflammation caused by epithelial barrier damage. Although the effect of A. muciniphila on intestinal inflammation has been gradually studied, how it works is still unclear. Meanwhile, factors including host, intestinal segmentation, age, intestinal disease, and diet, affecting the distribution of A. muciniphila in the GIT and how A. muciniphila interacts with the host to maintain intestinal health is mainly unknown. 
Dosage
 Follow your physician's guidance or instructions enclosed. 
Storage
 Keep dry in dark.
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