Customization: | Available |
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CAS No.: | N/a |
Formula: | Dpp IV |
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Dipeptidyl peptidase 4 (DPP-4) is a protein that plays a role in many physiological processes, including glucose metabolism, immune regulation, and the clearance of hormones that regulate glucose homeostasis:
Function
DPP-4 is a serine protease that cleaves peptides in the circulation, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Expression
DPP-4 is expressed in many tissues, including the lungs, intestines, kidneys, livers, brains, pancreases, and immune cells.
Role in diabetes
DPP-4 inhibitors are oral anti-diabetic drugs used to treat type 2 diabetes mellitus by improving glycemia and post-prandial lipid excursions.
Role in the immune system
DPP-4 regulates the functions of immune cells, including CD4(+) and CD8(+) T cells, B cells, NK cells, dendritic cells, and macrophages.
Role in virus
DPP-4 is a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with it.
Storage & Shelf Life
At least 24 months if store at room temperature, in a well-sealed package away from moisture and sunlight.
Physical & Chemical Properties | Microbiology | |||
Color | With proper color | Enzyme activity, U | As required | |
Aspect | Powder | Non LAB Count, CFU/g | <5000 | |
Odor | No abnormal odor | |||
Impurities | No visible foreign body | Coliform, CFU/g | <10 | |
Moisture, % | ≤5.0 | Yeast & Mold, CFU/g | ≤50 | |
Water activity | <0.12 | Diarrheagenic Escherichia coli (/25g) | Negative | |
Heavy Metals | ||||
Lead (Pb) ppm | <0.5 | Salmonella/25g | Negative | |
Arsenic (As) ppm | <0.5 | Staphylococcus aureus/25g | Negative | |
Cadmium (Cd) ppm | <1.0 | |||
Mercury (Hg) ppm | <0.1 | Shigella/25g | Negative |
NOP-Organic, cGMP, HACCP, ISO9001, ISO22000, Halal, Kosher
Inner packing: glass bottle