a Prevent and Treat Allergic Microbes Lactobacillus Rhamnosus

• Customization: Available
• CAS No.: N
• Formula: N
• Model NO.: LRYZU021
• Resource: Natural
• Smell: Addible
• Appearance: Beige Powder
• Storage: Low Temperature Against Light
• Transport Package: Plastic
• Specification: TBC
• Trademark: N
• Origin: China
• HS Code: 21069090
• Production Capacity: 5, 000kg/M

Product Description

   Introduction  
Lactobacillus rhamnosus has been found in many niches, including human intestine, vagina, mouth and dairy products. To intensively investigate the genomic diversity of this species, draft genomes of 70 L. rhamnosus strains isolated from different subjects were sequenced and further investigated. The pan-genome of L. rhamnosus was open. And gene-trait matching (GTM) was done to explore the carbohydrate utilization ability and antibiotic resistance, and to establish a pattern of gene existence/absence and growth/absence. There were no significant correlations between genetic diversity of the strains and the age or region of the donors. The current results extend the understanding of L. rhamnosus, which could be used as a reference for subsequent research as well as mining and application of the species.
    L. rhamnosus is a Gram-positive bacterium that exists in a variety of niches, such as the human intestine and vagina (Pascual et al., 2008). L. rhamnosus GG is one of the best commercialized strain among L. rhamnosus. It has a strong resistance to gastrointestinal digestion and potential probiotic characteristics. Previous studies on L. rhamnosus focused on its functional benefits including various diarrhea treatments, immunity improvement, and respiratory infections prevention (Barbieri et al., 2017; Evans et al., 2016). Phenotype studies were carried out, such as acid tolerance, bile salt tolerance, carbohydrate utilization and adherence to epithelial cells (Ceapa et al., 2016, 2015; Succi et al., 2005; Tripathi et al., 2013).
     Lactobacillus rhamnosus (L. rhamnosus) is a probiotic that has shown potential in preventing and treating allergic reactions: 

• Food allergies

L. rhamnosus GG (LGG) may help prevent food allergies, particularly cow's milk allergies, in infants. LGG may also help with allergic asthma caused by birch pollen. 

• Intestinal microbiota

L. rhamnosus may help regulate the intestinal microbiota, which can influence the immune system and tolerance to allergens. 

• Allergic response

L. rhamnosus may reduce the impact of allergic responses by downregulating the expression of IgE and histamine H4 receptors, and by enhancing mast-cell immune activity. 

• Immune homeostasis

L. rhamnosus may help improve intestinal homeostasis, which may alleviate allergies. 
L. rhamnosus is also used to treat diarrhea from antibiotics, eczema, hay fever, stomach pain, and canker sores. However, there is little scientific evidence to support its use for many of these conditions.
Prone to allergies and allergic reactions (atopic disease). Taking L. rhamnosus GG by mouth during pregnancy or breastfeeding, or giving it to the infant, seems to prevent some allergic conditions, such as asthma, runny nose, and eczema, in infants.

Dosage
 Follow physician's guidance or instruction enclosed. 
Storage
The recommended storage temperature for Lactobacillus rhamnosus (LR) depends on whether it is active or inactive, and the form it is in:

• Active (freeze-dried): Store at 0°F (-18°C)
• Inactive (spray-dried): Store at room temperature 

The survivability of LR decreases with increasing storage temperature and time. For example, in one study, LR inoculated peanut butter and stored at 37°C could not maintain the 6-log level for more than 6 weeks. In another study, the inactivation rate of LR was about four times faster at higher storage temperatures. 
LR is a friendly bacteria that is used in dietary supplements and functional foods. It is associated with boosting the immune system.

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LIST OF STRAINS
Probiotics	Strain Number	Type(CFU/g)
Lactiplantibacillus plantarum	Lp3a	5-500B
Lacticaseibacillus rhamnosus	LR05	5-400B
Lacticaseibacillus casei	LC11	5-400B
Lacticaseibacillus paracasei	LPC45	5-400B
Lactobacillus fermentum	LF021	5-300B
Lactobacillus salivarius	LS01	5-100B
Lactobacillus reuteri	LR06	5-200B
Lactobacillus acidophi/us	LA16	5-200B
Lactobacillus  helveticus	LH030/LZ-R-5	5-200B
Lactobacillus crispatus	LCP051	5-100B
Lactobacillus gasseri	LG021/LG019	5-200B
Lactobacillus johnsonii	LJ10	5-100B
Lactobacillus delbrueckii subsp. bulgaricus	LB45	5-20B
Bifidobacterium animalis subsp. lactis	Bla019	5-400B
Bifidobacterium animalis subsp. animalis	BA023	5-500B
Bifidobacterium breve	BB033	5-200B
Bifidobacterium longum subsp. longum	BL5b	5-100B
Bidobacterium longum subsp. infantis	BI08	5-50B
Bifidobacterium bifidum	BMC31	5-200B
Bifidobacterium adolesentis	BAA021	5-100B
Streptococcus salivarius subsp. thermophilus	ST076	5-300B
Pediococcus pentosaceus	PP016	5-300B
Pediococcus acidolactici	PAL31	5-400B
Leuconostoc mesenteroides subsp. mesenteroides	LCM020	5-200B
Weizmannia  coagulans	BC01	5-100B
Akkermansia  muciniphila	AMP018	5-200B